office hours

  • Monday     2:30 - 4:00

  • Thursday 9:00 - 10:30



  • The role of NADPH oxidase induced oxidative stress in inflammatory disease development.
  • The utilization of NMR spectroscopy in undergraduate laboraties to study the stereochemistry of addition reactions.

David Johnson



ISC 326J
1 College Circle
Geneseo, NY 14454

DSC 0008

David Johnson has been a member of the Geneseo faculty since 1991.

Faculty Information


  • Ph.D. (Chemistry) Montana State University
  • BA Hamline University


  • Welch Post Doctoral Fellow, Trinity University, San Antonio, TX
  • Visiting Professor of Chemistry, Carleton College, Northfield, MN

Research Interests

My research is directed at understanding the molecular basis of NADPH oxidase inhibition by apocynin (4-hydroxy-3-methoxyacetophenone). The activated NADPH oxidase complex produces reactive oxygen species which are involved in the early stage development of a series of inflammatory diseases such as atherosclerosis, diabetic retinopathy and asthma. A clearer understanding of this inhibition mechanism may lead to a novel therapy for diseases involving NADPH oxidase induced oxidative stress.

Publications and Professional Activities

  • Houser, K.R., Johnson, D.K. and Ishmael, F.T. "Anti-inflammatory Effects on Methoxyphenolic Compounds on Human Airway Cells" Journal of Inflammation, 2012, 9:6 (
  • Robert W. O'Donnell, David K. Johnson, Linda M. Ziegler Andrew J. DiMattina, Robert I. Stone, James A. Holland, “Endothelial NADPH Oxidase: Mechanism of Activation by Low-Density Lipoprotein” Endothelium, 2003, 10, 291-297.
  • Johnson, D.K.; O’Donnell, R.W.; Schillinger, K.J.; Kwiat, D.K.; Hughes, C.C; McNamara, E.J.; Ishmael, F.; Hogg, M.G., Santhanam, L., Ziegler, L.M.; Chang, M. Dordick, J.S. and Holland, J.A. “Metabolic Activation of an NADPH Oxidase Inhibitor: Apocynin, An o-Methoxy-4-Substituted Catechol” Endothelium, 2002, 9, 191-203.
  • Holland, J.A. and Johnson, D.K., “Use of NADPH Oxidase Inhibitors for the Manufacture of a Medicament for Prevention of Atherosclerosis” European Patent 861070B1, 2000.
  • Holland, J.A.; Gross, R.A.; O’Donnell, R.W.; Chang, M.-M.; Johnson, D.K.; and Zeigler, L.M. “Low-Density Lipoprotein Induced Actin Cytoskeleton Reorganization in Endothelial Cells: Mechanisms of Action” Endothelium, 2001, 8, 117-135.
  • Holland, J.A.; O’Donnell, R.W.; Chang, M.; Johnson, D.K. and Ziegler, L.M. “Endothelial Cell Oxidant Production: Effect of NADPH Oxidase Inhibitors” Endothelium, 2000, 7, 109-119.
  • Holland, J.A. and Johnson, D.K. , “Prevention of Atherosclerosis Using NADPH Oxidase Inhibitors” United States Patent 5902831, 1999.
Spring 2016 Classes

CHEM 213:
Organic Chemistry II

    Continuation of CHEM 211 with emphasis on the biochemically important alcohol, amine, carbonyl and aromatic functional groups. Structure elucidation by spectroscopic methods is also explored. Prerequ
    isites: CHEM 211. Credits: 3(3-0) Offered every spring
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CHEM 216:
Organic Chemistry Laboratory

    Laboratory practices in representative organic preparations and procedures. Prerequisites: /Corequisite: CHEM 211 or CHEM 223. Offered every fall and spring

CHEM 313:
Lab Tech in Organic Chem I

    A laboratory course devoted to the synthesis, separation, and identification of organic compounds, utilizing modern instrumental methods. Prerequisites: (CHEM 213 or CHEM 223) and CHEM 216 and CHEM 20
    9. Offered every spring
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