Cytosine DNA Methylation and Transcriptional Repression in African Trypanosomes


Associate Professor Kevin Militello

Department: Biology

Funding Source: National Institute of Allergy & Infectious Disease

Period of Funding: February 15, 2012 - January 31, 2015

Award Total: $387,768

There is an urgent need to prevent Human African Trypanosomiasis, a potentially fatal disease that impacts tens of thousands of people each year. Our studies of cytosine DNA methylation in Trypanosoma brucie may reveal the mechanism by which the parasites regulate expression of surface antigens and evade the human immune system. Engineered parasites lacking DNA methylation may over-express surface antigens and serve as a vaccine.