Cytosine DNA Methylation and Transcriptional Repression in African Trypanosomes


Associate Professor Kevin Militello

Department: Biology

Funding Source: National Institute of Health

Period of Funding: April 1, 2009 - March 31, 2011

Award Total: $193,376

There is an urgent need for new therapeutics to prevent and treat Human African Trypanosomiasis, as there is currently no effective vaccine and drug treatments are toxic and unreliable. Our studies of Cytosine DNA methylation in Trypanosoma brucei may reveal the mechanism by which the parasites regulate expression of surface antigens and evade the human immune system. Drugs that target cytosine DNA methylation could possibly eliminate parasite immune system evasion or transmission.