- Postdoctoral Fellow - University of Wisconsin
- Ph.D. in Cell Biology, 2001 - University of Illinois
- B.S. in Molecular and Cell Biology, 1995 - Penn State University
In the Cox Laboratory, we use the soil nematode, C. elegans, as a model system for studying morphogenesis. Morphogenesis is the process by which tissues acquire three-dimensional shapes during development. In particular, we study the role of the actin regulator, tropomodulin, in regulation of intestinal development. The aim of our research is to gain new insights into the basic mechanisms of how biological tubes are built. This is important, in part, because many of our tissues and organs and built from tubes (e.g. lungs, vascular system, kidneys and glands).
Publications and Professional Activities
- Grana TM, Cox EA, Lynch AM, and Hardin J. (2010) SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation. Developmental Biology 344: 731-44.
- Yamashiro S, Cox EA, Baillie DL, Hardin J, and Ono S. (2008) Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1, and profilin. Journal of Cell Science 121: 3867-77.
- Stevenson TO, Mercer KB, Cox EA, Szewczyk NJ, Conley CA, Hardin J, and Benian GM. (2007) unc-94 encodes a tropomodulin in Caenorhabditis elegans. Journal of Molecular Biology 374: 936-50.
- Cox EA and Hardin J. (2004) Sticky worms: adhesion complexes in C. elegans. Journal of Cell Science 117: 1885-1897.
- Cox EA, Tuskey C and Hardin J. (2004) Cell adhesion receptors in C. elegans. Journal of Cell Science 117: 1867-1870.
- Pettitt J*, Cox EA*, Broadbent ID, Flett A and Hardin J. (2003) The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. Journal of Cell Biology 162: 15-22. *authors contributed equally
- Cox EA, Bennin D, Doan AT, O'Toole T and Huttenlocher A. (2003) RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Molecular Biology of the Cell 14: 658-669.
- Cox EA, Sastry SK and Huttenlocher A. (2001) Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases. Molecular Biology of the Cell 12: 265-277.
- Palecek SP, Cox EA, Huttenlocher A, Lauffenburger DA and Horwitz AF. (1999) Integrin adhesion in cell migration. Advances in Molecular and Cell Biology 28: 367-388.
- Cox EA and Huttenlocher A. (1998) Regulation of integrin-mediated adhesion during cell migration. Microscopy Research and Technique 43: 412-419.