Office Hours FALL 2015

  • Monday 900-1000
  • Tuesday 1000-1100
  • Thursday 330-430

Announcements

  • I usually have several students in my laboratory.  Please contact me directly to determine if there are openings for undergraduate student research.

 

 

Interests

  • Infectious diseases (parasites and bacteria), modified DNA bases, epigenetics, genomics

 

 

Kevin Militello

Associate Professor of

Biology

Integrated Science Center 357
1 College Circle
Geneseo, NY 14454
585-245-5312
militello@geneseo.edu

Dr. Kevin Militello has been a member of the Geneseo faculty since 2005.

Faculty Information

Education

  • Postdoctoral Fellow, Harvard School of Public Health, 2005
  • Ph.D. in Microbiology, SUNY Buffalo, 2000
  • B.S. in Biology, SUNY Buffalo, 1995

Research Interests

Currently, my laboratory is investigating the relationship between the modified DNA base 5-methylcytosine and gene transcription in several organisms.

Publications and Professional Activities

  • Militello KT, Chen L, Ackerman SE, Mandarano AH, and Valentine EL. A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing. 2013 Mol Biochem Parasitol. Accepted for publication.
  • Militello KT, Mandarano AH, Varechtchouk O, and Simon RD. 2013. Cytosine DNA methylation influences drug resistance in Escherichia coli through increased expression of SugE. FEMS Microbiology Letters. Accepted for publication.
  • Militello KT. 2013. Studying epigenetic DNA modifications in undergraduate laboratories using complementary bioinformatic and molecular approaches. Biochemical and Molecular Biology Education. 41:334-340.
  • Militello KT, Simon RD, Qureshi M, Maines R, VanHorne ML, Hennick SM, Jayakar SK, Pounder S. 2012. Conservation of Dcm-mediated cytosine DNA methylation in Escherichia coli. FEMS Microbiol Lett. 2012 328:78-85.
  • Sims JS, KT Militello, PA Sims, VP Patel, JM Kasper, and DF Wirth. 2009. Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic development cycle. Eukaryotic Cell 8:327-338.
  • Militello KT, P Wang, SK Jayakar, RL Pietrasik, CD Dupont, K Dodd, AM King, and PR Valenti. 2008. African trypanosomes contain 5-methylcytosine in nuclear DNA. Eukaryotic Cell 7:2012-2016.
  • Militello KT, P Refour, CA Comeaux, MT Duraisingh. 2008. Antisense RNA and RNAi in protozoan parasites: Working hard or hardly working? Mol. Biochem. Parasitol. 157:117-126.
  • Gunasekera AM, A Myrick, KT Militello, JS Sims, CK Dong, T Gierhan, K Le Roch, E Winzeler, and DF Wirth. 2007. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol. Biochem. Parasitol. 153:19-30.
  • Militello KT, V Patel, AD Chessler, JK Fisher, JM Kasper, AM Gunasekera, and DF Wirth. 2005. RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. RNA 11:365-370.
  • Militello KT, M Dodge, L Bethke, and DF Wirth. 2004. Identification of regulatory elements in the Plasmodium falciparum genome. Mol. Biochem. Parasitol. 134:75-88.
  • Ryan CM, KT Militello, and LK Read. 2003. Polyadenylation regulates the stability of Trypanosoma brucei mitochondrial RNAs. J. Biol. Chem. 278:32753-32762.
  • Militello KT and DF Wirth. 2003. A new reporter gene for transient transfection of Plasmodium falciparum. Parasitol. Res. 89:154-157.
  • Militello KT, ML Hayman, and LK Read. 2000. Transcriptional and post-transcriptional in organello labelling of Trypanosoma brucei mitochondrial RNA. Int. J. Parasitol. 30:643-647.
  • Militello KT and LK Read. 2000. UTP-dependent and -independent pathways of mRNA turnover in Trypanosoma brucei mitochondria. Mol. Cell. Biol. 20:2308-2316.
  • Han Y, YM Loo, KT Militello, and T Melendy. 1999. Interactions of the papovavirus DNA replication initiator proteins, bovine papillomavirus type I E1 and simian virus 40 large T antigen, with human replication protein A. J. Virol. 73:4899-4907.
  • Militello KT and LK Read. 1999. Coordination of kRNA editing and polyadenylation in Trypanosoma brucei mitochondria: complete editing is not required for long poly(A) tract addition. Nucleic Acids Res. 27:1377-1385.
  • Murphy ER, A Dickenson, KT Militello, and TD Connell. 1999. Genetic characterization of wild-type and mutant fur genes of Bordetella avium. Infect. Immun. 67:3160-3165.
  • Read LK, KT Militello, and GE Nerantzakis. 1999. Cloning and characterisation of cDNA encoding the Trypanosoma brucei ribosomal protein L24. Int. J. Parasitol. 29:601-605.
  • Connell TD, A Dickenson, AJ Martone, KT Militello, MJ Filiatraut, ML Hayman, and J Pitula. 1998. Iron starvation of Bordetella avium stimulates expression of five outer membrane proteins and regulates a gene involved in acquiring iron from serum. Infect. Immun. 66:3597-3605.
Fall 2015 Classes

BIOL 216:
Biology Second Year Laboratory

    This course is designed for second year Biology and Biochemistry majors. It will include modules centered around Ecology, Genetics and Cell biology. Students will be introduced to select experimenta
    l techniques and experimental design that reflect contemporary practices in each of these areas. The course will count as a 200 level lab for the Biology BS and BA and as an elective for the Biochemistry BS degree. Restricted to pre-biology majors, majors, and minors. Prerequisites: BIOL 117 and BIOL 119.
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BIOL 322:
Molecular Biology

    An advanced course dealing with genetic and regulatory mechanisms at the cell and molecular level. Students may receive Biology credit for this course or Biol 304, but not both. Restricted to majors.
    Prerequisites: BIOL 300, and (CHEM 300 or CHEM 302 or BIOL 335). Offered every fall
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BIOL 390:
Molecular Techniques

    An introduction to basic techniques commonly used in biotechnology. Laboratory exercises include DNA, RNA, and protein manipulations, web-based sequence analysis, and the use of associated apparatus.
    Lectures cover background information of the techniques and their applications. Restricted to majors. Prerequisites: BIOL 300 and one of the following: (BIOL 216, BIOL 223, BIOL 230, BIOL 301, CHEM 301, BIOL 330).
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