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Kazushige Yokoyama

Professor
ISC 326F
(585) 245-5320
yokoyama@geneseo.edu
Recent Research Update No. 1  K. Yokoyama and A. Ichiki 
"Nano-size Dependence in the Adsorption by the SARS-CoV-2 Spike Protein over Gold Colloid" 
[Colloid and Surfaces A,Volume 615, pp. 126275-126281 

s protein at interface

 

Recent Research Update No. 2 
K. Yokoyama and A. Ichiki,
"Spectroscopic Investigation of SARS-CoV-2 Spike Protein"
[Colloid  and Interface Science Communication, Vol 40, pp. 100356-100362 (2021)]
  The reversible aggregation of SARS-CoV-2 S protein coated gold nano colloid.The trend of shift in SPR band, Δ l peak Equation previously stated, for tested colloidal particles in this study. (pH ~7 for n = 1, pH ~10 for odd n, and pH ~3 for even n).

Recent Research Update No. 3
Amyloidogenic peptides coated gold colloid

[Pod Cast]  [Science Outreach Article, see Issue 116 pp. 110-113]

SUNY Geneseo COVID19 Study Group (Team Yokovid)

Curriculum Vitae

Education

  • B.S. & M.S. University of Kobe, Japan (with Professor Hajime Kato)

  • Ph.D. University of Colorado (with Professor Carl Lineberger)

  • Post-Doctoral Fellow at University of Minnesota (with Professor Paul Barbara)

Publications: Papers

  • Kazushige Yokoyama and Akane Ichiki, "Nano-size Dependence in the Adsorption by the SARS-CoV-2 Spike Protein over Gold Colloid" Colloid and Surfaces A (in press)

  • K. Yokoyama and A. Ichiki, "Nano-Size Dependence in the Adsorption by the SARS-CoV-2 Spike Protein over Gold Colloid", Colloids and Surfaces A, Vol. 40 pp. 100356-100362 (2021)

  • K. Yokoyama and A. Ichiki " Spectroscopic Investigation on the Affinity of SARS-CoV-2 Spike Protein to Gold Nano-Particles", Colloid and Interface Science communication, in press.
    https://www.sciencedirect.com/science/article/abs/pii/S2215038220301369

  • K. Yokoyama and A. Ichiki, “Adsorption of Amyloidogenic Peptides at Nano-Scale Interface Studied by Spectroscopic Approach”, Journal of Visualized Experiments, Under the Review.

  • K. Yokoyama and A. Ichiki, “What can peptide-coated nanoparticles tell us about the causes of dementia?”, Research OutreachJournal of Visualized Experiments, pp. 110-113, Issue 116 (2020)
    http://cdn.researchoutreach.org/Flipbooks/RO116/index.html#

  • K. Yokoyama, K. Brown, P. Shevlin, J. Jenkins, E. D'Ambrosio, N. Ralbovsky, J. Battaglia, I. Deshmukh, and A. Ichiki, “Examination of Adsorption Orientation of Amyloidogenic Peptides Over Nano-Gold Colloidal Particles’ Surfaces”, Int. J. Mol. Sci., Vol 20, pp. 5354-5380 (2019).
    https://www.mdpi.com/1422-0067/20/21/5354

  • • K. Yokoyama, H. Chen, A. Islam, I. Deshmukh, P. Shevlin, K. Brown, and A. Ichiki, "Dynamical Investigation of Adsorption Orientation of Amyloid Beta Peptide 1-40 at Nano-Scale Gold Surface”, BAOJ Chemistry, Vol. 5 (1), pp. 1-20 (2019).

  • K. Yokoyama, D. Noh, M. Sayed, C. Berti, and P. Shevlin "nanoscale Interfacial interaction of Amyloid beta peptide 1-40with ThT", BAOJ Chemistry, Vol. 3 (3), pp. 31-42 (2017)

  • K. Yokoyama, C. D. Catalfamo, and M. Yuan, “Reversible peptide oligomerization over nanoscale gold surfaces”, AIMS Biophysics, Vol.2 (4), pp. 679-695 (2015).

  • R. E. McKnight, D. Jackson, K. Yokoyama, “Temperature dependence of Amyloid beta12-28”, Europian Biophysics Journal, Vol. 42, No. 6, pp. 495-501 (2013)

  • K. Yokoyama and R. Priefer, “Self-assembly of Amyloid Beta Peptide over Dialkoxy Disulfide Functionalized Nano Gold Colloidal Particles”, International Review of Biophysical Chemistry, Vol. 2 No. 5, pp.174-183, (2011)

Publications: Text Book & Book Chapters

  • [TEXT BOOKS]
    Text Book
    K. Yokoyama “Modern Physical Chemistry for Bioscience Students - Friendly and Short Cut Guide for Physical Chemistry” (2011) Linus Publication, ISBN# 1-60797-185-2 First Edition (604 pages), ISBN# 1-60797-246-8 Second Edition.(618 pages), ISBN# 1-60797-337-5 Third Edition.(592  pages), ISBN978-1-60797-897-8 (2020) [Click]

    K. Yokoyama (Editor) “Frontiers in Nanoscience for Biomedical Research”  Research Signpost, ISBN# 978-81-308-0537-5, (2014).

  • Kazushige Yokoyama, Kieran Brown, Peter Shevlin, Jack Jenkins, Elizabeth D’Ambrosio, Nicole Ralbovsky, Jessica Battaglia, Ishan Deshmukh and Akane Ichiki, "Examination of Adsorption Orientation of Amyloidogenic Peptides Over Nano-Gold Colloidal Particle Surfaces" pp. 75-102 in " Designer Biopolymers Self-Assembling Proteins and Nucleic Acids " Edited by Ayae Sugawara-Narutaki Yukiko Kamiya MDPI, Basel, Switzerland (2020)
    ISBN 978-3-03936-370-4
    https://www.mdpi.com/books/pdfview/book/2605

  • K. Yokoyama and A. Ichiki "Chapter 3: Oligomerization and Adsorption Orientation of Amyloidogenic Peptides over Nano-Gold Colloidal Particle Surfaces” pp. 139-194 in Advances in Chemical Research, Ed. by James C. Taylor, Nova Science Publishing, Hauppauge, NY, USA. (2020) ISBN: 978-1-53617-627-8.
    https://novapublishers.com/shop/advances-in-chemistry-research-volume-6…

  • K. Yokoyama, K. Brown, P. Shevlin, J. Jenkins, E. D’Ambrosio, N. Ralbovsky, J. Battaglia, I. Deshmukh and Akane Ichiki, “Examination of Adsorption Orientation of Amyloidogenic Peptides Over Nano-Gold Colloidal Particle Surfaces”, e-Book Book Chapter, Prime Archives in Molecular Biology, VideLeaf.
    https://videleaf.com/examination-of-adsorption-orientation-of-amyloidog…

  • Kazushige Yokoyama “Controlling Reversible Self Assembly Path of Amyloid Beta Peptide over Gold Colloidal nanoparticle’s Surface” Book Chapter in “Nanoscale Spectroscopy with Applications” Sarhan M. Musa –Ed (CRC Press-Taylor and Francis Group, LLC) ISBN# 9781466568532 (2013) [http://www.crcpress.com/product/isbn/9781466568532]

  • Kazushige Yokoyama “Nano Size Dependent Properties of Colloidal Surfaces” Book Chapter in “Colloids: Classification, Properties and Applications” (Nova Science Publishing) (2012)

Research Interests

Self-assembly of Amyloid b (Initial on-set mechanism of Alzheimer’s disease) or a- synuclein (Initial on-set mechanism of Parkinson’s disease)

Self-assembly of Amyloid b.

 

Functionalization of nanocolloidal particles 
(Collaboration with Professor Ron Priefer-Western New England University)

Functionalization of nanocolloidal particles.

 

Control of diffusion rate in silica based sol-gel matrix by nanoscale dopants 

Control of diffusion rate in silica based sol-gel matrix by nanoscale dopants

Journal Editorial Role

Guest Editor: MDPI-"Surfaces" Special Issue "The Study of Adsorption to the Surfaces" 

Editorial Board Member of AIMS Biophysics

Textbook s

K. Yokoyama (Editor) “Frontiers in Nanoscience for Biomedical Research”  Research Signpost, ISBN# 978-81-308-0537-5, (2014)

Frontiers in Nanoscience for Biomedical Research

K. Yokoyama
Friendly and Short Cut Guide for Physical Chemistry
Modern Physical Chemistry for Bioscience Students

(4th edition) Linus Leraning  ISBN978-1-60797-897-8 (2020) 
[Click]

Physical Chemistry by Yokoyama

Problemset 
Modern Physical Chemistry for Bioscience Students
Linus Learning (2021) ISBN 978-1-60797-931-9 
[Click]

Problemset

Classes

  • CHEM 104: Chemistry & Society

    A terminal one-semester course designed to acquaint non-science students with how chemistry and science affect their lives. Chemical principles are applied to problems of current interest, such as energy and pollution. Methods which chemists and other scientists use in their attempts to solve such problems are illustrated.

  • CHEM 105: N/Chemistry & Society Lab

    A terminal one-semester laboratory designed to acquaint non-science students with how chemistry and science affect their lives. Experiments are applied to problems of current interest, such as acid rain. Methods which chemists and other scientists use in their attempts to solve such problems are introduced.

  • CHEM 116: Chemistry I

    An introduction to some of the fundamental principles of chemistry. Topics include introduction to chemistry, stoichiometric principles, atomic structure and nature of the periodic table, chemical bonding, reactions in solutions, solution stoichiometry, thermochemistry, and trends in the physical and chemical properties of elements and their compounds.

  • CHEM 203: N/Principles of Chemistry I

    An introduction to some of the fundamental principles of chemistry, including stoichiometry, atomic structure and bonding, periodicity, classification of reactions, thermochemistry, gases, intermolecular forces and changes of state, solutions, and kinetics. Topics will include new areas of research and applications to current problems in the health sciences, environmental sciences, and chemical safety.

  • CHEM 329: Topics in Physical Chemistry

    An in depth study of one or more selected topics in advanced physical chemistry with emphasis on modern concepts and recent developments. Topics for this course could include chemical thermodynamics, statistical thermodynamics, physical chemistry of solutions, atomic spectroscopy and structure, molecular spectroscopy and structure, chemical applications of group theory, quantum chemistry, kinetic molecular theory, chemical kinetics, advanced instrumental techniques. This course may be repeated for credit whenever new topics are offered.